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No Priors

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ai52 episodes indexed

No Priors

Sarah Guo & Elad Gil

VC-hosted interviews with AI founders and researchers on frontier model progress, compute bottlenecks, and startup dynamics — including the infrastructure race that space-based compute pitches are part of.

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Episodes

RSS · updated 16:00Z●LIVE

S1 · E175Rethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen SteinGoogle’s purchase of Spirit Airlines’ data out of bankruptcy signaled a shift in how the tech world values real-world datasets. Although compute and models get much of the attention, in this landscape, it’s data that is a company’s protectiAug 27 · 35 min
S1 · E174From Restoring Sight to Reimagining the Brain, with Max HodakMax Hodak, co-founder and CEO of Science Corporation, joins Sarah Guo to discuss the future of vision, brain-computer interfaces, and the human experience. Max explains how Science’s PRIMA retinal implant could restore functional vision forAug 20 · 32 min
S1 · E173What Chess.com Teaches US About Superhuman Capabilities, with CEO Erik AllebestIn a world of infinite gaming and entertainment possibilities, how does a centuries-old game stay so popular? Chess.com co-founder and CEO Erik Allebest joins Sarah Guo to explain how the evolution of technology has kept people coming back Aug 13 · 46 min
S1 · E172Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & EladIs the tech industry moving too quickly, or are founders letting fear of AI labs stunt their ambitions? Sarah and Elad explore the current landscape of artificial intelligence, venture capital, and startup dynamics. They discuss the realitiAug 6 · 39 min
S1 · E171Building an Autonomous Enterprise for Real-World Services with Netic Founder Melisa TokmakWhen your AC fails in a heatwave, you don’t want a busy signal; you need a solution. Netic founder and CEO Melisa Tokmak joins host Elad Gil to explain how Netic’s autonomous AI platform acts as an intermediary between companies and customeJul 31 · 34 min
S1 · E170Building an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley TangDoorDash is not just a delivery company. From its inception, co-founders Andy Fang and Stanley Tang operated it as a robotics and autonomy company. Andy and Stanley join Sarah Guo to explain how autonomous tech and AI are reshaping consumerJul 23 · 49 min
S1 · E169Travel Through the Lens of AI with with Booking.com CEO Glenn FogelWhen Glenn Fogel joined Priceline in 2000, the business was worth a few hundred million dollars. One week later, the Nasdaq peaked, eventually sending its stock down to a dollar a share. But over 25 years later, Booking Holdings has scaled Jul 9 · 41 min
S1 · E168How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah TaylorWhile the rest of the nuclear industry still relies on simulations and paper designs, Valar Atomics is busy splitting atoms. In fact, they just powered an NVIDIA Blackwell chip directly with a live nuclear reactor in order to power the worlJul 2 · 1h 1m
S1 · E167Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam BrownWhen a new AI model drops, it’s judged based on a static benchmark grid that doesn’t account for how long the model is allowed to think. How then should we measure a model’s true capability? OpenAI research scientist Noam Brown returns to tJun 26 · 36 min
S1 · E166Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu TanAt 66 years old, instead of heading towards retirement, former Cadence CEO and legendary investor Lip-Bu Tan decided to take on the hardest job in tech: turning Intel around. Elad Gil and Sarah Guo sit down with Intel CEO Lip-Bu Tan to talkJun 18 · 45 min
S1 · E165Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex RivesBiohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of frontier AI and biological data, that goal may have been too conservative. In thisJun 10 · 56 min
S1 · E164We Need An Ecosystem in AI, And Every Company Can Win A Place In ItWhat does it mean for a business to truly operate at the AI frontier? In a special crossover episode at Microsoft Build, Sarah Guo and Elad Gil team up with Latent Space host “swyx” to talk with Microsoft Chairman and CEO Satya Nadella abouJun 4 · 42 min
S1 · E163Building an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar KoganWe are now closer than ever before to living in a world where AI agents are smart enough to run our power grids and manage water supplies. How do we keep them from going rogue? Sarah Guo sits down with Maxim Bar Kogan, founder and CEO of OnMay 28 · 41 min
S1 · E162The Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew FeldmanCompanies in Silicon Valley from Nvidia to AMD are racing to fuel the AI revolution with postage stamp-sized AI chips. Meanwhile, a chip the size of a dinner plate just fueled a $63 billion IPO for Cerebras. Elad Gil and Sarah Guo sit down May 21 · 31 min
S1 · E161Pax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob HelbergSecuring AI dominance requires more than just semiconductors; it demands a complete overhaul of how the West manages everything that goes into them, from rare earth minerals to actuators. Enter: Pax Silica. Sarah Guo and Elad Gil sit down wMay 14 · 38 min
S1 · E160Amex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander TaubmanThe world’s first AI-take-private just proved that AI can revolutionize the real economy. Long Lake Management co-founder and CEO Alexander Taubman joins Elad Gil to discuss his firm’s agreement to acquire the legacy platform American ExpreMay 11 · 22 min
S1 · E156Baseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference CloudBaseten CEO and co-founder Tuhin Srivastava sits down with Sarah Guo and Elad Gil to discuss the rapid growth of AI inference demand, Baseten’s 30x growth, and why inference is becoming the strategic “last market.” Tuhin Srivastava argues tMay 1 · 43 min
S1 · E158 SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp HerzigMore than fifty years ago, the modern idea of the standard enterprise software was birthed at SAP. Now, after managing companies through technological shifts from the mainframe to mobile, SAP is at the forefront of closing the AI adoption gApr 23 · 46 min
S1 · E157 Scaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermottFew teens are business owners, but by age 16, Bill McDermott had purchased and was running a local deli. Now he runs leading global technology powerhouse ServiceNow, a company that is defining how the world’s largest organizations transformApr 17 · 57 min
S1 · E156The Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy AllaireAI agents can already collaborate, but they lack a trustworthy medium in which to store value and execute contracts. Enter Circle’s Arc Blockchain, an economic “operating system” designed for a world where machines drive the real economy. CApr 9 · 44 min
—AI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam FedusWhat happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic Labs, which is pioneering an AI foundation lab for atoms. Liam discusses how he Apr 3 · 29 min
S1 · E154Andrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AIWhat happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of models, the future of engineering and education, thinking about impact on jobs, andMar 20 · 1h 7m
S1 · E153 From Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon LastNotion isn’t designing AI agents that just use tools. Their agents can autonomously build their own integrations, as well as write the code needed to finish a task. Sarah Guo sits down with Notion Co-Founder Simon Last to explore Notion’s rMar 12 · 29 min
S1 · E152How Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil TiwariBy the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The question isn’t who has the best model, but who has the most creative financing to build out AI infrastructure and beyond. Sarah Guo is joined by Neil TiFeb 26 · 36 min
S1 · E151From SaaS to AI-First: How Companies Are Reshaping InnovationIn this episode of No Priors, Sarah and Elad dive into the evolving landscape of software, exploring how AI is transforming the traditional SaaS model. They discuss whether SaaS as we know it is coming to an end, what new business and salesFeb 19 · 41 min
S1 · E150Rivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ ScaringeAutonomous vehicle technology has moved past human-coded rules and into an era of neural networks and custom computer chips. And to solve the most difficult driving scenarios, electric vehicle company Rivian abandoned its original technologFeb 12 · 32 min
S1 · E149 Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave BaszuckiFrom “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is using AI technology to build the “Holodeck” envisioned in science fiction decades ago. Sarah Guo and Elad Gil sit down with Roblox CEO Dave Baszucki at RFeb 5 · 44 min
S1 · E148Why Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura DemingWhat if we could pause biological time to wait for a cure for a disease? Thanks to innovations and research in reversible cryopreservation, this possibility is no longer just science fiction. Sarah Guo sits down with Laura Deming, CEO and cJan 29 · 31 min
S1 · E147No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ DesaiWhy are there only a handful of companies in the world with over $10 billion in pure-play software revenue? CJ Desai believes the reason is that products are replaceable, but platforms are forever. For No Priors’ very first live from MongoDJan 22 · 37 min
S1 · E146AI and the Future of Warfare with US Under Secretary of War Emil MichaelToday’s arms race looks a little different from those of the past. Under the Trump administration, the US Department of War (DoW) is deploying generative AI to millions of employees in order to maintain a strategic edge over our global adveJan 15 · 45 min
S1 · E145NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” NarrativeEven if ChatGPT never existed, the tech giant NVIDIA would still be winning. The end of Moore’s Law—says NVIDIA President, Founder, and CEO Jensen Huang—makes the shift to accelerated computing inevitable, regardless of any talk of an AI “bJan 8 · 1h 16m
S1 · E144The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad GilPundits are screaming about the so-called “AI bubble.” But historically slow-to-adopt industries like medicine and law are actually embracing AI at an unprecedented speed. Sarah Guo and Elad Gil look ahead to 2026, breaking down the major tDec 19, 2025 · 41 min
S1 · E143The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati StaniszewskiImagine learning chess from a grand master, or negotiating tactics from an expert FBI hostage negotiator. ElevenLabs’ voice AI technology is making that unlock possible. Sarah Guo sits down with Mati Staniszewski, co-founder of ElevenLabs, Dec 11, 2025 · 42 min
S1 · E142Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe PereyraIn just over three years, Harvey has not only scaled to nearly one thousand customers, including Walmart, PwC, and other giants of the Fortune 500, but fundamentally transformed how legal work is delivered. Sarah Guo and Elad Gil are joinedDec 5, 2025 · 44 min
S1 · E141 Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng ChiThe robotics industry is on the cusp of its own “GPT” moment, catalyzed by transformative research advances. Enter Memo, the first general-intelligence personal robot, focused on taking on your chores to give back your time. Sarah Guo sits Nov 19, 2025 · 39 min
S1 · E140How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith WickramasekaraBringing new drugs to market is a costly, time-consuming endeavor. On top of that, most medicines fail at some point in the research and development phase. Sarah Guo is joined by Sajith Wickramasekara, co-founder and CEO of Benchling, a comNov 13, 2025 · 48 min
S1 · E137Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar RamaswamySnowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits down with Snowflake CEO Sridhar Ramaswamy to discuss his first 18 months at the helNov 6, 2025 · 42 min
S1 · E138The Best of 2025 (So Far) with Sarah Guo and Elad Gil2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and scientific minds in the field of AI today. So we’re revisiting a few of our favorite Oct 31, 2025 · 19 min
S1 · E137Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach LloydFor decades, the developer terminal has remained largely unchanged. But for Warp CEO and co-founder Zach Lloyd, reinventing this core tool is the key to unlocking AI agents for coding, debugging, and automating the entire development procesOct 23, 2025 · 27 min
S1 · E136Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach DellWith demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its future from the ground up. Zach sits down with Elad Gil to talk about Base Power’s Oct 15, 2025 · 32 min
S1 · E135Humans&: Bridging IQ and EQ in Machine Learning with Eric ZelikmanThe AI industry is obsessed with making models smarter. But what if they’re building the wrong kind of intelligence? In launching his new venture, humans&, Eric Zelikman sees an opportunity to shift the focus from pure IQ to building modelsOct 9, 2025 · 37 min
S1 · E134The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh AroraBetween the future of search, the biggest threats in cybersecurity, and the jobs and platforms of tomorrow, Nikesh Arora sees one common thread connecting and transforming them all—AI. Sarah Guo and Elad Gil sit down with Nikesh Arora, CEO Oct 4, 2025 · 58 min
S1 · E133Reinventing K-12 Education Using AI with Alpha School Principal Joe LiemandtWhat if kids could master their academics in just two hours a day and spend the rest of their time developing real-world skills they’re passionate about? Joe Liemandt, founder of the software company Trilogy, is doing just that. Sarah Guo aSep 25, 2025 · 1h 2m
S1 · E132AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse ZhangThe traditional call center may soon be a thing of the past. Jessie Zhang is building AI agents designed to replace monotonous human labor and transform how consumers interact with brands. Elad Gil sits down with Jesse Zhang, co-founder andSep 18, 2025 · 31 min
S1 · E131Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AIFrom negotiating with world leaders to partnering with top entrepreneurs, businessman and investor Jared Kushner has traveled the unique path of bringing private sector knowledge to government work and back again. Jared Kushner joins Sarah Sep 15, 2025 · 58 min
S1 · E130A New Operating System for Physicians with OpenEvidence Founder Daniel NadlerHow does a new technology get adopted by 40% of American doctors in just 18 months? In an era where the golden age of biotechnology has also created a dark age of physician burnout, OpenEvidence found the answer by fundamentally changing hoSep 5, 2025 · 45 min
—Reshaping America’s Economy for the Superintelligence Century with Jacob HelbergAI doomers say that the technology will be the ultimate job-killer. But Jacob Helberg wants people to see AI as a tech that will boost, not replace, human workers and give them superpowers. Under Secretary of State for Economic Growth, EnerAug 28, 2025 · 41 min
— How Agentic AI is Transforming The Startup Landscape with Andrew NgAndrew Ng has always been at the bleeding edge of fast-evolving AI technologies, founding companies and projects like Google Brain, AI Fund, and DeepLearning.AI. So he knows better than anyone that founders who operate the same way in 2025 Aug 21, 2025 · 42 min
S1 · E127Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan PatelWhat would it take to challenge Nvidia? SemiAnalysis Founder and CEO Dylan Patel joins Sarah Guo to answer this and other topical questions around the current state of AI infrastructure. Together, they explore why Dylan loves Android producAug 14, 2025 · 47 min
—The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew PrinceCloudflare has spent nearly fifteen years making the Internet faster, more reliable, and more secure. So now that AI systems are changing the way we interact with the Internet, Cloudflare wants to help level the playing field for content crAug 7, 2025 · 45 min

Source: Episodes via the show's public RSS feed · as of Sep 1, 2026 16:00 UTC

Showing the 50 most recent episodes. Full archive on the show's site.

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